Basal insulin titration algorithms in patients with type 2 diabetes: the simplest is the best (?)

Basal insulin is the first and main component of therapy in patients with type 2 diabetes mellitus (T2DM). Based on shortcomings human NPH advantages provided by long-acting basal analogues, they are recommended for priority use T2DM. The leading factor success titration its dose achievement target range glycemia. Data from clinical trials real practice indicate that simpler algorithms ensure better glycemic goals a lower risk hypoglycemia. In addition, simple accepted increase satisfaction treatment. societies diabetologists ADA/EASD AACE/ACE recommend algorithms. Recent effectiveness glargine based INSIGHT algorithm, which, unlike traditional options changing 1–2 times week, involves daily correction 1 Unit, have proven safety. Most prefer this titration. same algorithm can be used fixed combination lixisenatide, which was also confirmed results trials. general, simplified correcting demonstrated their allow increasing percentage who manage to achieve goal without When prescribing insulin, physician must determine glycemia, demonstrate acceptable each patient will goal.